ENGINEERING NEW POSSIBILITIES
A microscopic world
A new possibility
Connecting nature’s precision with the possibilities of technology. We advance phage technologies and therapeutic research to address antimicrobial resistance.
WHY WE EXIST
Antimicrobial resistance, a challenge already here
New antimicrobial approaches begin with scientific investigation.
CHINA / 2024
6.97million isolates
Bacterial isolates included in national surveillance
GLOBAL / 2021
4.71million deaths
Estimated deaths associated with bacterial AMR
GLOBAL / 2050 FORECAST
8.22million deaths
Projected deaths associated with bacterial AMR
Sources and definitions ＋
China: CARSS included 6,969,416 bacterial isolates from 2,202 hospitals in the 2024 reporting period (October 2023–September 2024). The headline figure is rounded. Read the surveillance report ↗
Global figures: GBD 2021 Antimicrobial Resistance Collaborators, The Lancet (2024). The 95% uncertainty intervals for associated deaths are 4.23–5.19 million in 2021 and 6.85–9.65 million in 2050. These are estimates for the individual years, not cumulative totals. Read the original study ↗
OUR TECHNOLOGY
Turning scientific potential into progress
Engineering · Synthesis · Lytic spectrum & activity
PHAGE BANK
Discover what nature makes possible
Minimal Library + Comprehensive Database
For each target bacterium, we rapidly build a minimal phage library covering its prevalent strains, together with a comprehensive database of whole-genome sequences of phages and bacteria and their antagonistic relationships.
Natural Isolation + Engineering
The library combines high-performance lytic phages screened and isolated from nature with engineered phages purpose-constructed through gene editing, de novo synthesis and other technologies.
INTELLIGENT SCREENING
Find a match in complexity
Conventional PST + Intelligent Reporting
High-throughput screening of 96 phages per double-layer plate, with intelligent image recognition to identify lytic phages for automatic scoring and reporting of lytic activity; high-throughput screening of 96/384 phages per microplate, with real-time monitoring to assess phage lytic power and bacterial tolerance for automatic scoring and reporting.
Virtual PST
Based on the species, distinctive phenotypes and epidemiological characteristics of the target bacterium, we intelligently predict its best-matching type and select a targeted phage formulation accordingly; from the genomic sequence of the target bacterium, we intelligently predict which phages in the library can lyse it.
GENE EDITING
Expand the possibilities of gene editing
Production Host Engineering
The production host is engineered by knocking out genetic elements with potential impact on product safety to improve safety, and knocking out phage-resistance elements to increase phage yield.
Phage Engineering
Phages are engineered by replacing, modifying or synthesizing tail fiber proteins to broaden the receptor types they can bind, overcoming the narrow host coverage of natural phages, and by strengthening phage bactericidal elements while weakening bacterial counter-defense elements, overcoming bacterial tolerance.
FROM DISCOVERY TO APPLICATION
Built around real-world challenges
INSIDE CREATIPHAGE
See what moves us
A closer look at the questions we ask, the science we pursue and the direction we’re taking.
About CreatiPhageLATEST AT CREATIPHAGE
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