SCIENCE WITH PURPOSE
Focus on integrated phage solutions that precisely target drug-resistant bacteria
Founded by the top scientists in the field of clinical phage application, CreatiPhage (创噬纪) is the first company applying phage therapy to humans in China. Being a pun in Chinese, the name describes our goal: to create a new era of phage. We aim to overturn the antimicrobial resistance crisis by developing innovative drugs and individualized therapies with our cutting-edge phage and bacteria resources, and seeks to promote the overall development of phage therapy regionally and globally.
Explore our technologyOUR JOURNEY
From scientific insight to real-world applications
Dec 2025

Certified as National High-Tech Enterprise.
Related coverageMay 2025

Undertook a sub-project of China's national key special program for frontier biotechnology
Related coverageDec 2024

Pre-A financing closed, accelerating phage product commercialization.
Related coverageMay 2023

Wenzhou Capital and YS Capital invest in CreatiPhage, to accelerate the development of phage therapy.
Related coverageJun 2022

CreatiPhage announces collaboration agreements with Zhongshan Hospital Fudan University and Jiahui Health to develop innovative phage therapy.
Related coverageJan 2022

CreatiPhage Biotechnology was founded by the core scientists from the Shanghai Institute of Phage.
2018-2021

More than 50 patients with drug-resistant bacterial infections were enrolled in phage therapy study in Shanghai Public Health Clinical Center and Zhongshan Hospital Fudan University. The researchers published the first phage therapy cases in China, the world's first phage therapy for secondary bacterial infections with COVID-19, and the world's first dsRNA phage therapy in human.
Related coverageAug 2017

Tongyu Zhu, Xiaokui Guo and Li-Kuang Chen cofounded Shanghai Institute of Phage.
Related coverageMINDS BEHIND THE SCIENCE
Where clinical questions meet scientific discovery
Tongyu ZhuProfessor, Chief PhysicianZhongshan Hospital, Fudan University
Director of the Fudan University Phage Institute, Founding Director of the Shanghai Institute of Phage, and Chairman of the Alliance Phage of China. He previously served as Vice President of Zhongshan Hospital, Fudan University, Director of the Shanghai Public Health Clinical Center, and Deputy Director of the Shanghai Shenkang Hospital Development Center.
He initiated China’s first clinical trial of phage therapy, has led two major national phage therapy programs, and has achieved several landmark firsts in the field of phage therapy.
Li-Kuang ChenProfessor, Chief PhysicianHualien Tzu Chi Medical Center, Taiwan
Founding Deputy Director of the Shanghai Institute of Phage and AMR; Head of the Department of Laboratory Medicine and of Clinical Pathology at Hualien Tzu Chi Medical Center; Director of Experimental Diagnostics at the Tzu Chi University School of Medicine; Chair of the hospital’s Biosafety Committee; member of Taiwan’s eastern-region infection and epidemic management committee; and reviewer of level-3 biosafety containment facilities for the disease control authority. He is a certified specialist in clinical pathology, genomic medicine and emergency medicine.
He previously served as Dean of the Tzu Chi University School of Medicine, and held research appointments at the Institute of Molecular Biology of Academia Sinica in Taipei, the Icahn School of Medicine at Mount Sinai in New York, and the University of Pennsylvania.
Juan BaoChief PhysicianCreatiPhage
Before retirement she was Director and academic leader of the Department of Urology and Director of the Superbug Treatment Department at the Shanghai Public Health Clinical Center.
Her research focuses on urological cancers, urinary tuberculosis, refractory urinary tract infections and the clinical application of phage therapy. As clinical lead she participated in more than 30 phage therapy cases for urinary tract infections. She has published papers in journals including Emerging Microbes & Infections and Frontiers in Cellular and Infection Microbiology, and was first author of the first reported phage therapy case paper in China.
Bijie HuProfessor, Chief PhysicianZhongshan Hospital, Fudan University
Grade-II professor, Changjiang Scholar of the Ministry of Education, and recipient of the State Council Special Allowance. He is Director of the Department of Infectious Diseases and of the Infection Management Department at Zhongshan Hospital, Fudan University; Deputy Director of the Shanghai Institute of Respiratory Diseases and Head of its Pulmonary Infection Research Laboratory; Director of the Shanghai Hospital Infection Quality Control Center; and Deputy Director of the Fudan University Phage Research Institute.
He served on the national and Shanghai COVID-19 medical treatment expert panels and chaired Shanghai’s expert panel on COVID-19 hospital infection prevention and control. He is a member of the academic committee of the Shanghai Institute of Phage and AMR; Vice Chair of the Chinese Medical Association’s branch of bacterial infection and antimicrobial resistance control; Vice Chair of the National Health Commission’s expert committee on healthcare-associated infection prevention; Director of the National Health Commission’s hospital administration institute training base for bacterial and fungal infection diagnosis and treatment; a World Health Organization (WHO) expert on multidrug-resistant organisms and healthcare-associated infection prevention; and founder of the Shanghai International Forum for Infection Control (SIFIC). Under his leadership, the Zhongshan infection diagnosis, treatment and prevention center received the 2020 Shanghai Municipal Government Quality Gold Award.
His main research direction is the precise diagnosis, treatment and prevention of infectious diseases. He has led more than ten projects funded by the National Natural Science Foundation of China, subtasks of the Ministry of Science and Technology’s major research programs, the Shanghai Science and Technology Commission, and the Shanghai Shenkang Hospital Development Center.
Xiaokui GuoDistinguished ProfessorShanghai Jiao Tong University
The source lists Xiaokui Guo as Distinguished Professor at Shanghai Jiao Tong University; Deputy Director of the National Center for Tropical Diseases Research; Executive Vice Dean of the university’s School of Global Health; Vice Dean of the Shanghai–Ottawa Joint School of Medicine; and Deputy Director of the Shanghai Institute of Phage and AMR.
His professional appointments include chair of the Chinese Preventive Medicine Association’s microecology branch; chair of the Chinese Society for Microbiology’s medical microbiology and immunology committee and its science communication and education committee; and vice president and secretary-general of the Shanghai Society for Microbiology. He is a nationally recognized distinguished university teacher and outstanding teacher. He leads the national model and shared course Medical Microbiology and edited Pathogen Biology textbooks in the national undergraduate and graduate textbook programs for the 11th and 12th Five-Year Plans.
Jinhong QinProfessorShanghai Jiao Tong University
Jinhong Qin is a professor at Shanghai Jiao Tong University School of Basic Medical Sciences. The source lists her as vice chair of the youth committee of the Chinese Preventive Medicine Association’s microecology branch; secretary and member of the bacteriology group of the Chinese Society for Microbiology’s medical microbiology and immunology committee; and a member of committees on infectious microecology, special pathogens and Shanghai preventive microecology.
Her research focuses on phages and the prevention and control of resistant bacteria. The source reports more than 20 SCI-indexed papers and leadership or participation in projects funded by the National Natural Science Foundation, major national programs, Shanghai’s science authority and the Ministry of Education. She edited The Human Microbiome and Health and contributed to textbooks on pathogenic microbiology and the human microbiome.
Jingmin GuLeading Professor, Doctoral SupervisorJilin University
Jingmin Gu is a leading professor and doctoral supervisor at Jilin University. His research addresses the need to overcome antimicrobial-resistant bacteria through therapeutic phages and antibacterial proteins targeting important resistant zoonotic pathogens, as well as the mechanisms of phage–host interactions.
He has led national research projects including an Excellent Young Scientists Fund award, general grants from the National Natural Science Foundation, and a National Key R&D Program subproject. The source cites publications in journals including PLOS Pathogens and Biosensors and Bioelectronics.
Nannan WuAssociate Research FellowCreatiPhage
Co-founder and CEO of CreatiPhage Biotechnology, Associate Researcher at the Fudan University Phage Institute, and industry mentor for master’s students at the College of Food Science and Technology, Huazhong Agricultural University. Before joining CreatiPhage, he was an Associate Research Fellow and master’s supervisor at the Shanghai Institute of Phage, Shanghai Public Health Clinical Center.
His work focuses on the research and application of medical phage therapy. He has led a subtask of the Ministry of Science and Technology’s frontier biotechnology major program, general and young-scientist projects of the National Natural Science Foundation of China, a general project of the Shanghai Natural Science Foundation, and Pioneer Program projects, and has led or contributed to numerous phage therapy papers, consensus statements, standards and guidelines, as well as monographs and textbooks including Phagology and Microbial Virology.
He currently serves as a member of the Phage Technology Committee of the Chinese Society of Biotechnology, head of the Alliance Phage of China’s vice-chair unit, editorial board member of Bacteriophage and Microbes & Immunity, scientific editor of Military Medical Research, and expert of the virtual teaching and research office for microbial virology, a key area of virology.
Mengjun ChengAssistant Research FellowShanghai Public Health Clinical Center
Mengjun Cheng received her PhD from Jilin University. The source lists her as an assistant research fellow at Shanghai Public Health Clinical Center and the Shanghai Institute of Phage and AMR.
Her work concerns clinical phage therapy, phage antibacterial proteins and molecular mechanisms of bacterial resistance to phages. She has led one Young Scientists Fund project of the National Natural Science Foundation of China and one youth clinical-research project funded by the Shanghai health authority. The source reports seven first- or co-first-author SCI-indexed papers in journals including Applied and Environmental Microbiology, Viruses and Frontiers in Microbiology.
A CENTURY OF EXPLORATION
Brief History of Phage Therapy
Félix d'Hérelle discovered, named and pioneered phage therapy.
9 phage-based antimicrobial pipelines in clinical development were included in the 2021 WHO antimicrobial pipelines report (up to Nov. 2021).
Explore the full timeline and historical map+
- 1917
Félix d'Hérelle discovered, named and pioneered phage therapy.
Related source ↗ - 1928
Alexander Fleming discovered penicillin. Ten years later, penicillin was commercially available and widely used in clinical practice.
- 1958
Professor YU He (余㵑), director of Shanghai Institute of Immunology, led the first case of personalized phage therapy in China.
Related source ↗ - 2016
Margaret Chan (陈冯富珍), then Director-General of the World Health Organization (WHO), stressed in her speech at the United Nations that "antibiotic resistance may lead to the end of modern medicine". The next year, WHO announced 12 superbugs, including Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae, which are in urgent need of new antibacterial drug research and development.
Related source ↗ - 2017
The U.S. FDA approved 'Tom Patterson Case' for compassionate phage therapy for the first time.
Related source ↗ - 2018
Shanghai Institute of Phage announced the first "Mr. Sha Case" successfully cured by phage therapy since the implementation of China's ethical approval system.
Related source ↗ - 2019
The results of 'Phagoburn trial', a multinational clinical trial of phage therapy against Pseudomonas aeruginosa burn infections, were published in Lancet Infectious Diseases. The first-in-human treatment of gene-editing phage in the U.S. was published in Nature Medicine.
Related source ↗ - 2022
9 phage-based antimicrobial pipelines in clinical development were included in the 2021 WHO antimicrobial pipelines report (up to Nov. 2021).
Related source ↗

INVESTORS
Shared conviction, continued progress
YS Capital+
YScapital focusing on early-stage equity investment in high-end medical apparatus entrepreneurship projects with original technology. The management team has a deep medical industry background, extensive industry resources and rich experience in venture capital. It has the strong support of many influential clinical academicians, industry elites and medical innovation forces in China. YScapital continues to pay attention to new technologies and new directions of medical apparatus, researches, invests and cultivates leading technology enterprises with the spirit of craftsman, focuses on building an innovative ecosystem dominated by pan-vascular medical apparatus, and unswervingly builds itself into the most professional early investment institution for medical apparatus. (website: ysventures.cn)
Wenzhou Capital+
Wenzhou Capital is a professional market-oriented investment institution with mixed ownership of state-owned assets and shares. The company focuses on the concept of "taking root in industry and deeply cultivating medicine", and focuses on the investment in the biomedical field. The core team has senior industry and investment background in the biomedical field. The company attaches great importance to the in-depth research of the industry, adheres to the principle of sound and rational investment, and sincerely helps the development of enterprises. Wenzhou Investment has established extensive and close cooperation with scientific research and industry in the field of medicine. Wenzhou Capital has successively invested in competitive innovative biotech enterprises including TJ Biopharma, Ab&B Bio-Tech, TYK Medicines, Sinomune Pharmaceutical, Zhida Pharma, Phanes Therapeutics, Minova Pharma, Poclight Biotech and GenFleet Therapeutics . It has won awards such as Best China Pharma R&D Investor and Best Investment Case in the China Venture Capital Awards 2020–2021.(WeChat:文周投资)
Xuhui Sci-Tech Innovation Investment+
Xuhui Sci-Tech Innovation Investment: a wholly owned fund management company under Xuhui Capital. Centering on the dual objectives of government functions and enterprise economic performance, and in line with the different development stages of enterprises, it has established four self-managed funds—High-Quality Incubator, Sci-Tech Innovation Investment, Guangqi Huizhi (光启汇质), and Guangqi Huichan (光启汇产)—to provide full-lifecycle investment and financing services and use investment to foster a virtuous cycle of “technology–industry–finance.”
