ABOUT

About CreatiPhage

SCIENCE WITH PURPOSE

Focus on integrated phage solutions that precisely target drug-resistant bacteria

Founded by the top scientists in the field of clinical phage application, CreatiPhage (创噬纪) is the first company applying phage therapy to humans in China. Being a pun in Chinese, the name describes our goal: to create a new era of phage. We aim to overturn the antimicrobial resistance crisis by developing innovative drugs and individualized therapies with our cutting-edge phage and bacteria resources, and seeks to promote the overall development of phage therapy regionally and globally.

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Introducing CreatiPhageOpen full video

OUR JOURNEY

From scientific insight to real-world applications

02

May 2025

May 2025 · Company milestone

Undertook a sub-project of China's national key special program for frontier biotechnology

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03

Dec 2024

Dec 2024 · Company milestone

Pre-A financing closed, accelerating phage product commercialization.

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04

May 2023

May 2023 · Company milestone

Wenzhou Capital and YS Capital invest in CreatiPhage, to accelerate the development of phage therapy.

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05

Jun 2022

Jun 2022 · Company milestone

CreatiPhage announces collaboration agreements with Zhongshan Hospital Fudan University and Jiahui Health to develop innovative phage therapy.

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06

Jan 2022

Jan 2022 · Company milestone

CreatiPhage Biotechnology was founded by the core scientists from the Shanghai Institute of Phage.

07

2018-2021

2018-2021 · Company milestone

More than 50 patients with drug-resistant bacterial infections were enrolled in phage therapy study in Shanghai Public Health Clinical Center and Zhongshan Hospital Fudan University. The researchers published the first phage therapy cases in China, the world's first phage therapy for secondary bacterial infections with COVID-19, and the world's first dsRNA phage therapy in human.

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08

Aug 2017

Aug 2017 · Company milestone

Tongyu Zhu, Xiaokui Guo and Li-Kuang Chen cofounded Shanghai Institute of Phage.

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MINDS BEHIND THE SCIENCE

Where clinical questions meet scientific discovery

Tongyu ZhuTongyu ZhuProfessor, Chief PhysicianZhongshan Hospital, Fudan UniversityBiography +

Director of the Fudan University Phage Institute, Founding Director of the Shanghai Institute of Phage, and Chairman of the Alliance Phage of China. He previously served as Vice President of Zhongshan Hospital, Fudan University, Director of the Shanghai Public Health Clinical Center, and Deputy Director of the Shanghai Shenkang Hospital Development Center.

He initiated China’s first clinical trial of phage therapy, has led two major national phage therapy programs, and has achieved several landmark firsts in the field of phage therapy.

Li-Kuang ChenLi-Kuang ChenProfessor, Chief PhysicianHualien Tzu Chi Medical Center, TaiwanBiography +

Founding Deputy Director of the Shanghai Institute of Phage and AMR; Head of the Department of Laboratory Medicine and of Clinical Pathology at Hualien Tzu Chi Medical Center; Director of Experimental Diagnostics at the Tzu Chi University School of Medicine; Chair of the hospital’s Biosafety Committee; member of Taiwan’s eastern-region infection and epidemic management committee; and reviewer of level-3 biosafety containment facilities for the disease control authority. He is a certified specialist in clinical pathology, genomic medicine and emergency medicine.

He previously served as Dean of the Tzu Chi University School of Medicine, and held research appointments at the Institute of Molecular Biology of Academia Sinica in Taipei, the Icahn School of Medicine at Mount Sinai in New York, and the University of Pennsylvania.

Juan BaoJuan BaoChief PhysicianCreatiPhageBiography +

Before retirement she was Director and academic leader of the Department of Urology and Director of the Superbug Treatment Department at the Shanghai Public Health Clinical Center.

Her research focuses on urological cancers, urinary tuberculosis, refractory urinary tract infections and the clinical application of phage therapy. As clinical lead she participated in more than 30 phage therapy cases for urinary tract infections. She has published papers in journals including Emerging Microbes & Infections and Frontiers in Cellular and Infection Microbiology, and was first author of the first reported phage therapy case paper in China.

Bijie HuBijie HuProfessor, Chief PhysicianZhongshan Hospital, Fudan UniversityBiography +

Grade-II professor, Changjiang Scholar of the Ministry of Education, and recipient of the State Council Special Allowance. He is Director of the Department of Infectious Diseases and of the Infection Management Department at Zhongshan Hospital, Fudan University; Deputy Director of the Shanghai Institute of Respiratory Diseases and Head of its Pulmonary Infection Research Laboratory; Director of the Shanghai Hospital Infection Quality Control Center; and Deputy Director of the Fudan University Phage Research Institute.

He served on the national and Shanghai COVID-19 medical treatment expert panels and chaired Shanghai’s expert panel on COVID-19 hospital infection prevention and control. He is a member of the academic committee of the Shanghai Institute of Phage and AMR; Vice Chair of the Chinese Medical Association’s branch of bacterial infection and antimicrobial resistance control; Vice Chair of the National Health Commission’s expert committee on healthcare-associated infection prevention; Director of the National Health Commission’s hospital administration institute training base for bacterial and fungal infection diagnosis and treatment; a World Health Organization (WHO) expert on multidrug-resistant organisms and healthcare-associated infection prevention; and founder of the Shanghai International Forum for Infection Control (SIFIC). Under his leadership, the Zhongshan infection diagnosis, treatment and prevention center received the 2020 Shanghai Municipal Government Quality Gold Award.

His main research direction is the precise diagnosis, treatment and prevention of infectious diseases. He has led more than ten projects funded by the National Natural Science Foundation of China, subtasks of the Ministry of Science and Technology’s major research programs, the Shanghai Science and Technology Commission, and the Shanghai Shenkang Hospital Development Center.

A CENTURY OF EXPLORATION

Brief History of Phage Therapy

1917

Félix d'Hérelle discovered, named and pioneered phage therapy.

2022

9 phage-based antimicrobial pipelines in clinical development were included in the 2021 WHO antimicrobial pipelines report (up to Nov. 2021).

Explore the full timeline and historical map+
  1. 1917

    Félix d'Hérelle discovered, named and pioneered phage therapy.

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  2. 1928

    Alexander Fleming discovered penicillin. Ten years later, penicillin was commercially available and widely used in clinical practice.

  3. 1958

    Professor YU He (余㵑), director of Shanghai Institute of Immunology, led the first case of personalized phage therapy in China.

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  4. 2016

    Margaret Chan (陈冯富珍), then Director-General of the World Health Organization (WHO), stressed in her speech at the United Nations that "antibiotic resistance may lead to the end of modern medicine". The next year, WHO announced 12 superbugs, including Acinetobacter baumannii, Pseudomonas aeruginosa and Klebsiella pneumoniae, which are in urgent need of new antibacterial drug research and development.

    Related source ↗
  5. 2017

    The U.S. FDA approved 'Tom Patterson Case' for compassionate phage therapy for the first time.

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  6. 2018

    Shanghai Institute of Phage announced the first "Mr. Sha Case" successfully cured by phage therapy since the implementation of China's ethical approval system.

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  7. 2019

    The results of 'Phagoburn trial', a multinational clinical trial of phage therapy against Pseudomonas aeruginosa burn infections, were published in Lancet Infectious Diseases. The first-in-human treatment of gene-editing phage in the U.S. was published in Nature Medicine.

    Related source ↗
  8. 2022

    9 phage-based antimicrobial pipelines in clinical development were included in the 2021 WHO antimicrobial pipelines report (up to Nov. 2021).

    Related source ↗
Historical phage therapy map from the original website
Historical reference: the phage therapy map from the original website does not represent live statistics.

INVESTORS

Shared conviction, continued progress

YS CapitalYS Capital+

YScapital focusing on early-stage equity investment in high-end medical apparatus entrepreneurship projects with original technology. The management team has a deep medical industry background, extensive industry resources and rich experience in venture capital. It has the strong support of many influential clinical academicians, industry elites and medical innovation forces in China. YScapital continues to pay attention to new technologies and new directions of medical apparatus, researches, invests and cultivates leading technology enterprises with the spirit of craftsman, focuses on building an innovative ecosystem dominated by pan-vascular medical apparatus, and unswervingly builds itself into the most professional early investment institution for medical apparatus. (website: ysventures.cn)

Wenzhou CapitalWenzhou Capital+

Wenzhou Capital is a professional market-oriented investment institution with mixed ownership of state-owned assets and shares. The company focuses on the concept of "taking root in industry and deeply cultivating medicine", and focuses on the investment in the biomedical field. The core team has senior industry and investment background in the biomedical field. The company attaches great importance to the in-depth research of the industry, adheres to the principle of sound and rational investment, and sincerely helps the development of enterprises. Wenzhou Investment has established extensive and close cooperation with scientific research and industry in the field of medicine. Wenzhou Capital has successively invested in competitive innovative biotech enterprises including TJ Biopharma, Ab&B Bio-Tech, TYK Medicines, Sinomune Pharmaceutical, Zhida Pharma, Phanes Therapeutics, Minova Pharma, Poclight Biotech and GenFleet Therapeutics . It has won awards such as Best China Pharma R&D Investor and Best Investment Case in the China Venture Capital Awards 2020–2021.(WeChat:文周投资)

Xuhui Sci-Tech Innovation InvestmentXuhui Sci-Tech Innovation Investment+

Xuhui Sci-Tech Innovation Investment: a wholly owned fund management company under Xuhui Capital. Centering on the dual objectives of government functions and enterprise economic performance, and in line with the different development stages of enterprises, it has established four self-managed funds—High-Quality Incubator, Sci-Tech Innovation Investment, Guangqi Huizhi (光启汇质), and Guangqi Huichan (光启汇产)—to provide full-lifecycle investment and financing services and use investment to foster a virtuous cycle of “technology–industry–finance.”